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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC6
All Species:
17.88
Human Site:
Y710
Identified Species:
35.76
UniProt:
Q96SB8
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96SB8
NP_001135758.1
1091
126326
Y710
L
K
R
C
Q
L
H
Y
K
E
L
K
M
K
I
Chimpanzee
Pan troglodytes
XP_001136387
1091
126280
Y710
L
K
R
C
Q
L
H
Y
K
E
L
K
M
K
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532882
1606
180795
Y1225
L
R
R
R
Q
I
H
Y
R
E
L
K
V
K
I
Cat
Felis silvestris
Mouse
Mus musculus
Q924W5
1097
127179
Y716
L
K
R
C
Q
L
H
Y
K
E
I
K
M
K
I
Rat
Rattus norvegicus
NP_001101484
1097
127259
Y716
L
K
R
C
Q
L
H
Y
K
E
I
K
M
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505822
579
67328
M224
E
K
D
G
E
Q
L
M
K
R
I
E
E
L
K
Chicken
Gallus gallus
XP_419962
1096
127736
Q717
L
H
H
H
R
Q
H
Q
K
E
L
Q
I
K
I
Frog
Xenopus laevis
Q6P9I7
1128
130494
K748
L
R
Q
Y
H
N
S
K
K
Q
I
Q
I
D
L
Zebra Danio
Brachydanio rerio
NP_001121806
1090
126266
R715
L
R
R
A
Y
D
D
R
K
K
V
Q
E
R
S
Tiger Blowfish
Takifugu rubipres
Q802R8
1090
124790
Q716
L
R
R
T
Q
T
E
Q
K
T
T
E
V
K
T
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_794820
1236
142110
A829
I
E
G
D
Q
V
Y
A
G
A
E
Q
R
Y
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12749
1114
127990
L730
L
S
E
V
R
S
R
L
K
E
I
D
G
R
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
N.A.
63.3
N.A.
90
90.4
N.A.
38.1
59.7
60.5
51.4
45.9
N.A.
N.A.
N.A.
30.2
Protein Similarity:
100
100
N.A.
66.1
N.A.
96.3
96.2
N.A.
44
77.9
76.7
70.3
67
N.A.
N.A.
N.A.
50.9
P-Site Identity:
100
100
N.A.
66.6
N.A.
93.3
93.3
N.A.
13.3
46.6
13.3
20
33.3
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
100
N.A.
33.3
66.6
60
53.3
53.3
N.A.
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
47.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
0
9
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
34
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
9
0
9
9
0
0
0
0
9
0
9
0
% D
% Glu:
9
9
9
0
9
0
9
0
0
59
9
17
17
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
9
9
0
0
0
0
9
0
0
0
9
0
0
% G
% His:
0
9
9
9
9
0
50
0
0
0
0
0
0
0
0
% H
% Ile:
9
0
0
0
0
9
0
0
0
0
42
0
17
0
50
% I
% Lys:
0
42
0
0
0
0
0
9
84
9
0
42
0
59
9
% K
% Leu:
84
0
0
0
0
34
9
9
0
0
34
0
0
9
17
% L
% Met:
0
0
0
0
0
0
0
9
0
0
0
0
34
0
0
% M
% Asn:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
9
0
59
17
0
17
0
9
0
34
0
0
0
% Q
% Arg:
0
34
59
9
17
0
9
9
9
9
0
0
9
17
0
% R
% Ser:
0
9
0
0
0
9
9
0
0
0
0
0
0
0
9
% S
% Thr:
0
0
0
9
0
9
0
0
0
9
9
0
0
0
9
% T
% Val:
0
0
0
9
0
9
0
0
0
0
9
0
17
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
9
0
9
42
0
0
0
0
0
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _